acute hepatitis as a manifestation of acute lymphoblastic leukemia

Unilateral Ptosis as Initial Manifestation of Acute Myeloid Leukemia

Abstract Background In Acute Myeloid Leukemia (AML), malignant clones of immature myeloid cells (primarily blasts) proliferate, replace bone marrow, circulate in blood and invade other tissues. The unique presentation of unilateral ptosis and unilateral eyelid swelling in AML has been reported during the present study. Case Report A 7-year-old girl was encountered with progressively increa...

Arthritis as presenting manifestation of acute lymphoblastic leukemia in children

Introduction At disease onset children with acute lymphoblastic leukemia (ALL) may present with arthralgia (join pain) or even signs of arthritis with joint swelling, redness, and restriction of motion. This might cause misdiagnosis and thereby lead to prolonged diagnostic delay. The present study aimed to identify ALL children with joint involvement and to compare their characteristics and out...

UBE2Q1, as Down Regulated Gene in Pediatric Acute Lymphoblastic Leukemia

Ubiquitin - proteasome system (UPS), the major protein degradation pathway in the cells, typically degrades short - lived and damaged proteins and regulates growth and stress responses. This pathway is altered in various cancers, including Acute Lymphoblastic Leukemia (ALL). ALL begins with a change in bone marrow cells and is the most common type of leukemia in children under 15 years. UBE2Q1...

unilateral malignant pleural effusion as an initial manifestation of acute lymphoblastic leukemia: a rare case report

unilateral malignant pleural effusion as an initial manifestation that leads to the diagnosis of an underlying acute lymphoblastic leukemia is a rare event. early and accurate diagnosis of this case is important for prompt and adequate therapy. we present the case of an18-year-old male who presented to the emergency department with severe respiratory distress. chest x-ray revealed a unilateral ...

Metronomic Effect as A New Hypothesis in Maintenance Therapy of Acute Lymphoblastic Leukemia

Bone Scintigraphy in Acute Lymphoblastic Leukemia

Leukemia is the most common childhood cancer and accounts for 30-40% of all malignancies. A retrospective review  was performed of the hospital records of 9 children, 6 boys and 3 girls, aged  from 2.5 to 15 years with ALL initially referred to Nemazee hospital Nuclear medicine center for whole body bone scanning between 2000 and 2002. Bone marrow pathology established ALL (L1) in two and ALL (...